Improved surface modification approach for micromechanical biosensors.

نویسندگان

  • Hongyan Gao
  • Koutilya R Buchapudi
  • Abraham Harms-Smyth
  • Marvin K Schulte
  • Xiaohe Xu
  • Hai-Feng Ji
چکیده

We have investigated the sensing performance of protein-based microcantilever biosensors prepared from multiple surface conjugation chemistries. The 11-mercaptoundecanoic acid monolayers were prepared according to both traditional and modified processes. In three protein-based biosensors, the modified process improved microcantilever sensing performance by increasing the bending amplitude, a critical step toward developing a cost-effective microcantilever-based sensor platform for medical diagnostics and environmental and drug screening applications. Scanning electron microscopy (SEM) images demonstrated that proteins immobilized on the microcantilever surface using the modified chemistry approach formed a compact layer.

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عنوان ژورنال:
  • Langmuir : the ACS journal of surfaces and colloids

دوره 24 2  شماره 

صفحات  -

تاریخ انتشار 2008